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Frequently Asked Questions

What is CANCER FUND?

CANCER FUND (also CANCER FUND Impact Investments®) is the community and platform operated by CXO Advisors & Management, LLC. It brings together oncologists, scientists, investors, patients, and survivors to identify and fund early-stage cancer innovation, and it acts as Manager of Cancer Fund I, LLC and other investment vehicles..

What's the difference between CANCER FUND and Cancer Fund I, LLC?

CANCER FUND is the community, platform, and manager — CXO Advisors & Management, LLC doing business as CANCER FUND. Cancer Fund I, LLC is a specific private fund, with its own investment objectives, managed by CANCER FUND. Capital committed by investors is invested into Cancer Fund I, LLC — not into CXO Advisors & Management, LLC.

What is a donor-advised fund (DAF)?

A donor-advised fund (DAF) is a charitable giving account held at a public charity. You may already have one — at a sponsor like Fidelity Charitable, DAFgiving360, Vanguard Charitable, ImpactAssets, or another. Donor-advised funds are governed by the Internal Revenue Code, including Sections 4966 and 4967. Note that two different things on our site are both called “DAF”: your personal DAF at any sponsor, and the CANCER FUND Community Donor Advised Fund (CFC-DAF) at ImpactAssets.

Is a contribution to the CANCER FUND Community Donor Advised Fund (CFC-DAF) tax-deductible?

Contributions to the CANCER FUND Community Donor Advised Fund (CFC-DAF) are made to ImpactAssets, Inc., a 501(c)(3) public charity, and may be tax-deductible to the extent permitted by applicable law. Contributions are irrevocable. Consult your tax advisor for your specific situation.

How does the CFC-DAF Donor Advisor role work?

Grants and investments from the CANCER FUND Community Donor Advised Fund (CFC-DAF) are made on the recommendation of the CFC-DAF Donor Advisor. ImpactAssets, as the sponsoring 501(c)(3), owns and administers the CFC-DAF and retains full legal discretion over its grant and investment decisions. The Donor Advisor recommends; ImpactAssets decides. Questions about the CFC-DAF, including its governance, should be directed to ImpactAssets at www.impactassets.org, the CFC-DAF’s sponsoring charity.

How do I give?

You can contribute to the CANCER FUND Community Donor Advised Fund (CFC-DAF) directly through ImpactAssets, recommend a grant from a DAF you already hold at another sponsor, or open a new DAF. Visit cancerfund.com/give for convenient links for each option.

What is the CANCER FUND Community Donor Advised Fund (CFC-DAF)?

The CFC-DAF is a donor-advised fund established at ImpactAssets, Inc., a registered 501(c)(3) public charity (EIN: 26-2048480), to support early-stage companies developing cancer innovation with the potential to improve patient outcomes. ImpactAssets owns and administers the CFC-DAF and retains full legal discretion over its grants and investments decisions. Contributions to the CFC-DAF are charitable, irrevocable, and may be tax-deductible to the extent permitted by applicable law.

What does Cancer Fund I, LLC invest in?
Cancer Fund I, LLC, invests in the gap that is generally too late for research grants but too early for most venture capital, those are often Pre-Seed, Seed, Seed+, and Series A, B, and could be Series C and D rounds. The companies Fund I invests in are typically developing one or more of the following innovations with the potential to benefit patients, survivors, and at-risk populations; their caregivers, medical professionals:
(1) Therapies and Management,
(2) Diagnostics and Monitoring, and
(3) Prevention and Enabling Technologies.
What companies has Cancer Fund I, LLC invested in?
You can review the companies in our portfolio at HERE.
Who can invest in Cancer Fund I, LLC?
Cancer Fund I, LLC is offered to accredited investors only, under Regulation D, Rule 506(c).
What return I can expect if I invest in Cancer Fund I, LLC?
Cancer Fund I, LLC invests in high-risk, early-stage companies. Returns on some early-stage companies can be significant, but there is no assurance Cancer Fund I will realize those returns. In fact, most early-stage companies fail and result in a total loss of invested capital. Investors who cannot afford to lose their entire investment should not invest in Cancer Fund I.

CANCER FUND and Cancer Fund I do not make investment recommendations or provide financial advice. We encourage you to speak with your financial advisor to determine what level of investment, if any, makes sense for you — and we’re happy to brief your advisor if that would help.

How are companies identified and chosen for Cancer Fund I, LLC?
Cancer Fund I, LLC focuses on early-stage companies that can be difficult to identify. Sometimes companies find us, and sometimes we find them through our research and scouting efforts. As of early 2026, we have identified over 1,000+ innovative cancer companies seeking more than $10B in funding, and that list is constantly expanding. Companies are welcome to submit a profile for funding consideration at cancerfund.com/capital.

Cancer Fund I generally invests through thematic cycles following a 5-step process that typically. We review submitted company profiles at the beginning of each cycle for fit with the cycle theme and Fund I investment objectives and priorities.

The Cancer Fund I, LLC Investment Committee makes all final investment decisions.

How much can I invest in Cancer Fund I, LLC and is there a minimum?
See Cancer Fund I subscription documents for current minimum and terms.
How do I start investing in Cancer Fund I, LLC?
Visitwww.cancerfund.com/invest
Can I give and invest?
Yes — and there is nothing stopping you from doing both. Giving and investing are completely separate transactions that serve different purposes. A charitable gift to the CFC-DAF funds the earliest-stage innovations with patient, mission-aligned capital. An investment in Cancer Fund I gives you a direct financial stake in a portfolio of those same innovations. Some members start by giving and explore investing later when they qualify. There is no required order, and no obligation to do both.
How does my contribution support cancer innovation?
Your contribution flows to early-stage cancer innovation through one of two paths. Charitable contributions go to the CANCER FUND Community Donor-Advised Fund (CFC-DAF) at ImpactAssets, which has deployed capital into Cancer Fund I, LLC. Cancer Fund I has made 14 investments across 10 portfolio companies working on therapies, diagnostics, and enabling technologies for cancer. Each investment is selected with input from our community of physicians, researchers, survivors, caregivers, and supporters — the people closest to cancer help decide where the capital goes.

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